In 1984, Gan signed a five-year contract with Tony Wong Company as a singer, one of the first two solo xinyao recording singers.
Gan sang the theme song, Youth 1 2 3, for the 1986 Singapore Broadcasting Corporation (SBC) Channel 8's drama The Happy Trio. In September 1986, Tony Wong Company would cease its operations, and had agreed to release Gan from her 5-year contract ahead of the clause which would abrogated the contract if the company did not release a new album for her within a year from her last release. In March 1987, Gan signed with the record label, Ocean Butterflies Music.
In 1988, Gan also made her acting debut in a Channel 8 drama, Song of Youth, about aspiring singers.[a] In the drama, she played an eponymous named undergraduate student whose personality matches her real self and writes lyrics for other. In promoting the drama, SBC held a concert which Gan also performed at. She left record label Ocean Butterflies Music and signed with recording company, WEA Records (now known as Warner Music Group). Production of her albums was still done by Ocean Butterflies Music.
From 2008, Gan had performed yearly at the annual Xinyao Reunion Concert series organised by TCR Music Station until 2018. In July 2014, she also performed at a xinyao concert held at Bras Basah Complex as part of the xinyao documentary film, The Songs We Sang.
Gan was married with two sons and a daughter and lived in Hong Kong with her family.
Gan was diagnosed with synovial sarcoma in 2013 and then early-stage breast cancer in 2014. She had five surgeries to remove four tumours and a lobe of her lung and were deemed tumour-free in 2016. She died on 22 September 2018 in Hong Kong.