William's great-grandfather, Edward Osler, was variously described as either a merchant seaman or a pirate. One of William's uncles (Edward Osler (1798–1863)), a medical officer in the Royal Navy, wrote the Life of Lord Exmouth and the poem The Voyage. (Osler, Edward, 1798–1863. The Voyage : a poem, written at sea, and in the West Indies, and illustrated by papers on natural history. London : Longman, 1830). William Osler's father, Featherstone Lake Osler (1805–1895), the son of a shipowner at Falmouth, Cornwall, was a former Lieutenant in the Royal Navy who served on HMS Victory. In 1831 Featherstone Osler was invited to serve on HMS Beagle as the science officer on Charles Darwin's historic voyage to the Galápagos Islands, but he turned it down because his father was dying. In 1833, Featherstone Osler announced he wanted to become a minister of the Church of England.
As a teenager, Featherstone Osler was aboard HMS Sappho when it was nearly destroyed by Atlantic storms and left adrift for weeks. Serving in the Navy, he was shipwrecked off Barbados. In 1837 Featherstone Osler officially retired from the Navy and emigrated to Canada, becoming a "saddle-bag minister" in rural Upper Canada. When Featherstone Osler and his bride, Ellen Free Picton, arrived in Canada, they were nearly shipwrecked again on Egg Island in the Gulf of Saint Lawrence. The Oslers had several children, including William, Britton Bath Osler, and Sir Edmund Boyd Osler.
Following post-graduate training under Rudolf Virchow in Europe, Osler returned to the McGill University Faculty of Medicine as a professor in 1874. Here he created the first formal journal club. During this time, he also showed interest in comparative pathology and is considered the first to teach veterinary pathology in North America as part of a broad understanding of disease pathogenesis. In 1884, he was appointed Chair of Clinical Medicine at the University of Pennsylvania in Philadelphia and in 1885, was one of the seven founding members of the Association of American Physicians, a society dedicated to "the advancement of scientific and practical medicine." When he left Philadelphia in 1889, his farewell address, "Aequanimitas", was on the imperturbability (calm amid storm) and equanimity (moderated emotion, tolerance) necessary for physicians.
In 1889, he accepted the position as the first Physician-in-Chief of the new Johns Hopkins Hospital in Baltimore, Maryland. Shortly afterwards, in 1893, Osler was instrumental in the creation of the Johns Hopkins School of Medicine and became one of the school's first professors of medicine. Osler quickly increased his reputation as a clinician, humanitarian, and teacher. He presided over a rapidly expanding domain. In the hospital's first year of operation, when it had 220 beds, 788 patients were seen for a total of over 15,000 days of treatment. Sixteen years later, when Osler left for Oxford, over 4,200 patients were seen for a total of nearly 110,000 days of treatment.
In the UK, he initiated the founding in 1907 of the Association of Physicians and was founding Senior Editor of its publication the Quarterly Journal of Medicine until his death.
In 1911, he initiated the Postgraduate Medical Association, of which he was the first President. In the same year, Osler was named a baronet in the Coronation Honours List for his contributions to the field of medicine.
In January 1919 he was appointed President of the Fellowship of Medicine  and was also in October 1919 appointed founding President of the merged Fellowship of Medicine and Postgraduate Medical Association, now the Fellowship of Postgraduate Medicine.
Perhaps Osler's greatest influence on medicine was to insist that students learn from seeing and talking to patients and the establishment of the medical residency. The latter idea spread across the English-speaking world and remains in place today in most teaching hospitals. Through this system, physicians in training make up much of a teaching hospital's medical staff. The success of his residency system depended, in large part, on its pyramidal structure with many interns, fewer assistant residents and a single chief resident, who originally occupied that position for years. While at Hopkins, Osler established the full-time, sleep-in residency system whereby staff physicians lived in the administration building of the hospital. As established, the residency was open-ended, and long tenure was the rule. Physicians spent as long as seven or eight years as residents, during which time they led a restricted, almost monastic life.
He wrote in an essay "Books and Men" that "He who studies medicine without books sails an uncharted sea, but he who studies medicine without patients does not go to sea at all." His best-known saying was "Listen to your patient, he is telling you the diagnosis", which emphasises the importance of taking a good history.
The contribution to medical education of which he was proudest was his idea of clinical clerkship – having third- and fourth-year students work with patients on the wards. He pioneered the practice of bedside teaching, making rounds with a handful of students, demonstrating what one student referred to as his method of "incomparably thorough physical examination." Soon after arriving in Baltimore, Osler insisted that his medical students attend at bedside early in their training. By their third year they were taking patient histories, performing physicals and doing lab tests examining secretions, blood and excreta.
He reduced the role of didactic lectures and once said he hoped his tombstone would say only, "He brought medical students into the wards for bedside teaching." He also said, "I desire no other epitaph … than the statement that I taught medical students in the wards, as I regard this as by far the most useful and important work I have been called upon to do." Osler fundamentally changed medical teaching in North America, and this influence, helped by a few such as the Dutch internistP. K. Pel, spread to medical schools across the globe.
Osler was a prolific author and a great collector of books and other material relevant to the history of medicine. He willed his library to the Faculty of Medicine of McGill University where it now forms the nucleus of McGill University's Osler Library of the History of Medicine, which opened in 1929. The printed and extensively annotated catalogue of this donation is entitled "Bibliotheca Osleriana: a catalogue of books illustrating the history of medicine and science, collected, arranged and annotated by Sir William Osler, Bt. and bequeathed to McGill University". Osler was a strong supporter of libraries and served on the library committees at most of the universities at which he taught and was a member of the Board of Curators of the Bodleian Library in Oxford. He was instrumental in founding the Medical Library Association in North America, alongside employee and mentee Marcia Croker Noyes, and served as its second president from 1901 to 1904. In Britain he was the first (and only) president of the Medical Library Association of Great Britain and Ireland and also a president of the Bibliographical Society of London (1913).
Osler was a prolific author and public speaker and his public speaking and writing were both done in a clear, lucid style. His most famous work, 'The Principles and Practice of Medicine' quickly became a key text to students and clinicians alike. It continued to be published in many ions until 2001 and was translated into many languages. It is notable in part for supporting the use of bloodletting as recently as 1923. Though his own textbook was a major influence in medicine for many years, Osler described Avicenna as the "author of the most famous medical textbook ever written". He noted that Avicenna's Canon of Medicine remained "a medical bible for a longer time than any other work". Osler's essays were important guides to physicians. The title of his most famous essay, "Aequanimitas", espousing the importance of imperturbability, is the motto on the Osler family crest and is used on the Osler housestaff tie and scarf at Hopkins.
Osler is well known in the field of gerontology for the speech he gave when leaving Hopkins to become the Regius Professor of Medicine at Oxford. "The Fixed Period", given on February 22, 1905, included some controversial words about old age. Osler, who had a well-developed humorous side to his character, was in his mid-fifties when he gave the speech and in it he mentioned Anthony Trollope's The Fixed Period (1882), which envisaged a college where men retired at 67 and after being given a year to settle their affairs, would be "peacefully extinguished by chloroform". He claimed that, "the effective, moving, vitalizing work of the world is done between the ages of twenty-five and forty" and it was downhill from then on. Osler's speech was covered by the popular press which headlined their reports with "Osler recommends chloroform at sixty". The concept of mandatory euthanasia for humans after a "fixed period" (often 60 years) became a recurring theme in 20th century imaginative literature—for example, Isaac Asimov's 1950 novel Pebble in the Sky. In the 3rd ion of his Textbook, he also coined the description of pneumonia as "the friend of the aged" since it allowed elderly individuals a quick, comparatively painless death: "Taken off by it in an acute, short, not often painful illess, the old man escapes those "cold gradations of decay" so distressing to himself and his friends." Coincidentally, Osler himself died of pneumonia.
Personal life and family
13 Norham Gardens: Sir William Osler's residence in Oxford
An inveterate prankster, he wrote several humorous pieces under the pseudonym "Egerton Yorrick Davis", even fooling the ors of the Philadelphia Medical News into publishing a report on the extremely rare phenomenon of penis captivus, on December 13, 1884. The letter was apparently a response to a report on the phenomenon of vaginismus reported three weeks previously in the Philadelphia Medical News by Osler's colleague Theophilus Parvin. Davis, a prolific writer of letters to medical societies, purported to be a retired U.S. Army surgeon living in Caughnawaga, Quebec (now Kahnawake), author of a controversial paper on the obstetrical habits of Native American tribes that was suppressed and unpublished. Osler would enhance Davis's myth by signing Davis's name to hotel registers and medical conference attendance lists; Davis was eventually reported drowned in the Lachine Rapids in 1884.
Throughout his life, Osler was a great admirer of the 17th century physician and philosopher Sir Thomas Browne.
He died at the age of 70, on December 29, 1919, in Oxford, during the Spanish influenza epidemic, most likely of complications from undiagnosed bronchiectasis. His wife, Grace, lived another nine years but succumbed to a series of strokes. Sir William and Lady Osler's ashes now rest in a niche in the Osler Library at McGill University. They had two sons, one of whom died shortly after birth. The other, Edward Revere Osler, was mortally wounded in combat in World War I at the age of 21, during the 3rd battle of Ypres (also known as the battle of Passchendaele). At the time of his death in August 1917, he was a second lieutenant in the (British) Royal Field Artillery; Lt. Osler's grave is in the Dozinghem Military Cemetery in West Flanders, Belgium. According to one biographer, Osler was emotionally crushed by the loss; he was particularly anguished by the fact that his influence had been used to procure a military commission for his son, who had mediocre eyesight. Lady Osler (Grace Revere) was born in Boston in 1854; her paternal great-grandfather was Paul Revere. In 1876, she married Samuel W. Gross, chairman of surgery at Jefferson Medical College in Philadelphia. Gross died in 1889 and in 1892 she married William Osler who was then professor of medicine at Johns Hopkins University.
Osler was a founding donor of the American Anthropometric Society, a group of academics who pledged to donate their brains for scientific study. Osler's brain was taken to the Wistar Institute in Philadelphia to join the Wistar Brain Collection. In April 1987 it was taken to the Mütter Museum, on 22nd Street near Chestnut in Philadelphia where it was displayed during the annual meeting of the American Osler Society.
Osler's nodes are raised tender nodules on the pulps of fingertips or toes, suggestive of subacute bacterial endocarditis. Osler described them as "ephemeral spots of a painful nodular erythema, chiefly in the skin of the hands and feet." Osler nodes are usually painful, as opposed to Janeway lesions which are due to emboli and are painless.
Osler's rule: States that a neurological defect has to be related to a specific lesion, in contrast to Hickam's dictum, which states that the neurological defect can be due to several lesions.
Osler's syndrome is a syndrome of recurrent episodes of colic pain, with typical radiation to back, cold shiverings and fever; due to the presence in Vater's diverticulum of a free-moving gallstone which is larger than the orifice.
^"Honours to Medical Men: Coronation Honours". Lancet. 178 (4609): 1874–1876. 1911. doi:10.1016/s0140-6736(01)58188-x. Sir William Osler, Regius professor of medicine in the University of Oxford, who is famous throughout two continents, has enriched the literature of medicine with many works of high scientific and literary value.
^Osler appointed President of the Inter-Allied Fellowship of Medicine. The Times. 14th January 1919.
^Cook G. John McAlister's other vision. Abingdon, Oxon: Radcliffe Publishing Limited; 2005 ISBN1-85775-789-0
^Journal of Perinatology (September 6, 2007). "Access : Avicenna (AD 980 to 1037) and the care of the newborn infant and breastfeeding". Journal of Perinatology. Nature. 28 (1): 3–6. doi:10.1038/sj.jp.7211832. PMID17805338.
^Hirshbein, Laura Davidow (September 24, 2001). "William Osler and The Fixed Period: Conflicting Medical and Popular Ideas About Old Age". Archives of Internal Medicine. 161 (17): 2074–8. doi:10.1001/archinte.161.17.2074. PMID11570935.
^Osler, William (1899). The principles and practice of medicine: designed for the use of practitioners and students of medicine. New York: Appleton and Company. p. 109.
^Davis, Egerton Yorrick (1999). Golden, Richard L (ed.). The Works of Egerton Yorrick Davis, MD: Sir William Osler's Alter Ego. Osler Library studies in the history of medicine, no. 3. Montreal: Osler Library, McGill University. ISBN978-0-7717-0548-9. OCLC48551127. A collection of writings by the fictitious surgical character created by Osler, E. Y. Davis
Osler, William (1969) . Francis, William W; Hill, Reginald H; Malloch, Archibald (eds.). Bibliotheca Osleriana: A Catalogue of Books Illustrating the History of Medicine and Science (Revised ed.). Montreal: McGill-Queen's University Press. ISBN978-0-7735-9050-2. OCLC75916. The Introduction and other orial matter is freely available on-line.