User talk:DMacks

Erich Clar page[]

I want to include a synthetic reaction that is known as Clar's reaction. It is of a certain class of cyclic ketones that condense with themselves when heated to 400 C in a mixture of zinc dust and zinc chloride.

Picture 13 white on black.jpg

I will add references and a description of what it is used for in synthesizing new polycyclic aromatic hydrocarbons.

Tech News: 2023-04[]

MediaWiki message delivery 23:44, 23 January 2023 (UTC)Reply[reply]

3-Methylornithine[]

The page itself has 2 different length of carbon... https://upload.wikimedia.org/wikipedia/commons/thumb/6/64/3-methylornithine.svg/330px-3-methylornithine.svg.png

https://upload.wikimedia.org/wikipedia/commons/thumb/7/71/Pyrrolysine.svg/330px-Pyrrolysine.svg.png

I'm pretty confused... I don't know what to change ^^

Sciencationelle (talk) 16:52, 26 January 2023 (UTC)Reply[reply]

@Sciencationelle The article is correct but could do with expansion. If you click on its reference doi:10.1002/anie.201301164, you'll see a diagram that shows how 3-methyl ornithine first forms a dipeptide with lysine and then an enzyme cyclises the ornithine portion to form the ring. Mike Turnbull (talk) 11:39, 30 January 2023 (UTC)Reply[reply]
Take a look at File:Pyrrolysine Synthesis (corrected).png. In your first step, you take lysine and label the reaction "methylation". If a new carbon becomes attached as you say, it would give methyllysine not methylornithine. Compare your second structure with File:3-methylornithine.svg. The reaction instead is an isomerization: instead of a new carbon added, the chain gets shortened by one to supply the methyl group. Then notice in your last step (the multiple-arrows) how to have to lose one of the black carbons in the chain. If your black-and-red structure were to be correct, wouldn't the final product have a six-membered ring rather than five? Look at how many carbons there are between the methyl group and the nitrogen. Mike Turnbull's DOI link is a good one. DMacks (talk) 03:18, 31 January 2023 (UTC)Reply[reply]

Thank you for just blanking that request. My gut said something was wrong with it, but I couldn't readily confirm it. —C.Fred (talk) 18:57, 29 January 2023 (UTC)Reply[reply]

@C.Fred: You're welcome! Google-translate of the Arabic helps for these sorts of things. DMacks (talk) 19:13, 29 January 2023 (UTC)Reply[reply]
Which I did, actually, but didn't get any results that let me anywhere useful. Maybe my Translate foo just isn't as strong as yours. :) —C.Fred (talk) 19:19, 29 January 2023 (UTC)Reply[reply]

Tech News: 2023-05[]

MediaWiki message delivery 00:03, 31 January 2023 (UTC)Reply[reply]