UGT2B10

UGT2B10
Protein UGT2B10 PDB 2o6l.png
Identifiers
AliasesUGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDsOMIM: 600070 MGI: 2140962 HomoloGene: 117389 GeneCards: UGT2B10
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001290091
NM_001075
NM_001144767

NM_153598

RefSeq (protein)

NP_001066
NP_001138239
NP_001277020

n/a

Location (UCSC)Chr 4: 68.82 – 68.83 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.[4][5] It is responsible for glucuronidation of nicotine and cotinine.[6][7]

See Also[]

References[]

  1. ^ a b c ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (July 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochemical and Biophysical Research Communications. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
  5. ^ "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".
  6. ^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.
  7. ^ Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, Ratain MJ, et al. (January 2015). "UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers". Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 94–104. doi:10.1158/1055-9965.EPI-14-0804. PMC 4294984. PMID 25277794.

Further reading[]