UGT2A1

UGT2A1
Identifiers
AliasesUGT2A1, UDPGT2A1, UDP glucuronosyltransferase family 2 member A1 complex locus
External IDsOMIM: 604716 MGI: 2149905 HomoloGene: 136808 GeneCards: UGT2A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252274
NM_001252275
NM_001301239
NM_006798
NM_001389565

NM_053184

RefSeq (protein)

NP_444414

Location (UCSC)Chr 4: 69.59 – 69.65 MbChr 5: 87.46 – 87.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene.[5][6]

Function[]

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[6] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell associated with COVID-19.[7]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173610 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000106677 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jedlitschky G, Cassidy AJ, Sales M, Pratt N, Burchell B (June 1999). "Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase". Biochem. J. 340 (3): 837–43. doi:10.1042/0264-6021:3400837. PMC 1220318. PMID 10359671.
  6. ^ a b "Entrez Gene: UGT2B1 UDP glucuronosyltransferase 2 family, polypeptide B1".
  7. ^ "The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia | medRxiv".

Further reading[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.