The opioid epidemic or opioid crisis is the rapid increase in the use of prescription and non-prescription opioid drugs in the United States and Canada beginning in the late 1990s and continuing throughout the first two decades of the 2000s. Opioids are a diverse class of moderately strong painkillers, including oxycodone (commonly sold under the trade names OxyContin and Percocet), hydrocodone (Vicodin), and a very strong painkiller, fentanyl, which is synthesized to resemble other opiates such as opium-derived morphine and heroin. The potency and availability of these substances, despite their high risk of addiction and overdose, have made them popular both as formal medical treatments and as recreational drugs. Due to their sedative effects on the part of the brain which regulates breathing, opioids in high doses present the potential for respiratory depression, and may cause respiratory failure and death.
According to the U.S. Drug Enforcement Administration, "overdose deaths, particularly from prescription drugs and heroin, have reached epidemic levels.":iii Nearly half of all opioid overdose deaths in 2016 involved prescription opioids. From 1999 to 2008, overdose death rates, sales, and substance abuse treatment admissions related to opioid pain relievers all increased substantially. By 2015, annual overdose deaths from heroin alone surpassed deaths from both car accidents and guns, with other opioid overdose deaths also on the rise.
Drug overdoses have since become the leading cause of death of Americans under 50, with two-thirds of those deaths from opioids. In 2016, the crisis decreased overall life expectancy of Americans for the second consecutive year. Overall life expectancy fell from 78.7 to 78.6 years. Men were disproportionally more affected due to higher overdose death rates, with life expectancy declining from 76.3 to 76.1 years. Women’s life expectancy remained stable at 81.1 years.
In 2016, over 64,000 Americans died from overdoses, 21 percent more than the almost 53,000 in 2015. By comparison, the figure was 16,000 in 2010, and 4,000 in 1999. While death rates varied by state, public health experts estimate that nationwide over 500,000 people could die from the epidemic over the next 10 years. In Canada, half of the overdoses were accidental, while a third was intentional. The remainder were unknown. Many of the deaths are from an extremely potent opioid, fentanyl, which is trafficked from Mexico. The epidemic cost the United States an estimated $504 billion in 2015.
CDC director Thomas Frieden said that "America is awash in opioids; urgent action is critical." The crisis has changed moral, social, and cultural resistance to street drug alternatives such as heroin. In March 2017, Larry Hogan, the governor of Maryland, declared a state of emergency to combat the opioid epidemic, and in July 2017 opioid addiction was cited as the "FDA's biggest crisis." On October 26, 2017, President Donald Trump concurred with his Commission's report and declared the country's opioid crisis a "public health emergency."
Opiates such as morphine have been used for pain relief in the United States since in 1800s, and were used during the American Civil War. Opiates soon became known as a wonder drug and were prescribed for a wide array of ailments, even for relatively minor treatments such as cough relief. Bayer began marketing heroin commercially in 1898. Beginning around 1920, however, the addictiveness was recognized, and doctors became reluctant to prescribe opiates. Heroin was made an illegal drug with the Anti-Heroin Act of 1924, in which the U.S. Congress banned the sale, importation, or manufacture of heroin.
In the 1950s, heroin addiction was known among jazz musicians, but still fairly uncommon among average Americans, many of whom saw it as a frightening condition. The fear extended into the 1960s and 1970s, although it became common to hear or read about drugs such as marijuana and psychedelics, which were widely used at rock concerts like Woodstock. Heroin addiction began to make the news when famous people such as Janis Joplin, John Belushi, Jim Morrison and Lenny Bruce, whom most people did not know were addicted, died from overdoses. During and after the Vietnam War, addicted soldiers returned from Vietnam, where heroin was easily bought. Heroin addiction grew within low-income housing projects during the same time period. In 1971, congressmen released an explosive report on the growing heroin epidemic among U.S. servicemen in Vietnam, finding that ten to fifteen percent were addicted to heroin. "The Nixon White House panicked," wrote political or Christopher Caldwell and declared drug abuse "public enemy number one". By 1973, there were 1.5 overdose deaths per 100,000 people.
Modern prescription opiates such as vicodin and percocet entered the market in the 1970s, but acceptance took several years and doctors were apprehensive about prescribing them. Until the 1980s, physicians had been taught to avoid prescribing opioids because of their addictive nature. A brief letter published in the New England Journal of Medicine (NEJM) in January 1980, titled "Addiction Rare in Patients Treated with Narcotics", generated much attention and changed this thinking. A group of researchers in Canada claim that the letter may have originated and contributed to the opioid crisis. The NEJM published its rebuttal to the 1980 letter in June 2017, pointing out among other things that the conclusions were based on hospitalized patients only, and not on patients taking the drugs after they were sent home. The original author, Dr. Hershel Jick, has said that he never intended for the article to justify widespread opioid use.
In the mid-to-late 1980s, the crack epidemic followed widespread cocaine use in American cities. The death rate was worse, reaching almost 2 per 100,000. In 1982, Vice President George H. W. Bush and his aides began pushing for the involvement of the CIA and the U.S. military in drug interdiction efforts, the so-called War on Drugs. By comparison, the opioid epidemic was killing on average 10.3 people per 100,000 in 2016, with the highest rates including over 30 per 100,000 in New Hampshire and over 40 per 100,000 in West Virginia.
According to the Substance Abuse and Mental Health Services Administration’s National Survey on Drug Use and Health, in 2016, more than 11 million Americans misused prescription opioids, nearly 1 million used heroin, and 2.1 million had an addiction to prescription opioids or heroin.
While rates of overdose of legal prescription opiates has leveled off in the past decade, overdoses of illicit opiates have surged since 2010, nearly tripling.
Between 4-6% of people who misuse prescription opioids turn to heroin, and 80% of heroin addicts began by abusing prescription opioids.
In 2014, it was estimated that more than half a million Americans had an addiction to heroin.
Oxycodone is the most widely used recreational opioid in America. The U.S. Department of Health and Human Services estimates that about 11 million people in the U.S. consume oxycodone in a non-medical way annually.
Oxycodone was first made available in the United States in 1939. In the 1970s, the FDA classified oxycodone as a Schedule II drug, indicating a high potential for abuse and addiction. In 1996, Purdue Pharma introduced OxyContin, a controlled release formulation of oxycodone. In 2007, Purdue paid $600 million in fines after being prosecuted for making false claims about the risk of drug abuse associated with oxycodone. In 2010, Purdue Pharma reformulated OxyContin, using a polymer to make the pills extremely difficult to crush or dissolve in water to reduce OxyContin abuse. The FDA approved relabeling the reformulated version as abuse-resistant.
OxyContin was removed from the Canadian drug formulary in 2012. In June 2017, the FDA asked the manufacturer to remove its injectable form of oxymorphone (Opana ER) from the US market, because the drug's benefits may no longer outweigh its risks, this being the first time the agency has asked to remove a currently marketed opioid pain medication from sale due to public health consequences of abuse.
Fentanyl, a newer synthetic opioid painkiller, is 50 to 100 times more potent than morphine and 30 to 50 times more potent than heroin, with only 2 mg becoming a lethal dose. It is pure white, odorless and flavorless, with a potency strong enough that police and first responders helping overdose victims have themselves overdosed by simply touching or inhaling a small amount. As a result, the DEA has recommended that officers not field test drugs if fentanyl is suspected, but instead collect and send samples to a laboratory for analysis. "Exposure via inhalation or skin absorption can be deadly," they state.
Fentanyl-related deaths increased by 540 percent across the United States since 2015. This accounts for almost "all the increase in drug overdose deaths from 2015 to 2016", according to a study published in the Journal of the American Medical Association.
Fentanyl-laced heroin has become a big problem for major cities, including Philadelphia, Detroit and Chicago. Its use has caused a spike in deaths among users of heroin and prescription painkillers, while becoming easier to obtain and conceal. Some arrested or hospitalized users are surprised to find that what they thought was heroin was actually fentanyl. According to CDC director Thomas Frieden:
As overdose deaths involving heroin more than quadrupled since 2010, what was a slow stream of illicit fentanyl, a synthetic opioid 50 to 100 times stronger than morphine, is now a flood, with the amount of the powerful drug seized by law enforcement increasing dramatically. America is awash in opioids; urgent action is critical.
According to the Centers for Disease Control and Prevention (CDC), death rates from synthetic opioids, including fentanyl, increased over 72% from 2014 to 2015. In addition, the CDC reports that the total deaths from opioid overdoses may be under-counted, since they do not include deaths that are associated with synthetic opioids which are used as pain relievers. The CDC presumes that a large proportion of the increase in deaths is due to illegally-made fentanyl; as the statistics on overdose deaths (as of 2015) do not distinguish pharmaceutical fentanyl from illegally-made fentanyl, the actual death rate could, therefore, be much higher than reported.
Those taking fentanyl-laced heroin are more likely to overdose because they do not know they also are ingesting the more powerful drug. The most high-profile death involving an accidental overdose of fentanyl was singer Prince.
Fentanyl has surpassed heroin as a killer in several locales: in all of 2014 the CDC identified 998 fatal fentanyl overdoses in Ohio, which is the same number of deaths recorded in just the first five months of 2015. The U.S. Attorney for the Northern District of Ohio stated:
One of the truly terrifying things is the pills are pressed and dyed to look like oxycodone. If you are using oxycodone and take fentanyl not knowing it is fentanyl, that is an overdose waiting to happen. Each of those pills is a potential overdose death.
In 2016, the medical news site STAT reported that while Mexican cartels are the main source of heroin smuggled into the U.S., Chinese suppliers provide both raw fentanyl and the machinery necessary for its production. In British Columbia, police discovered a lab making 100,000 fentanyl pills each month, which they were shipping to Calgary, Alberta. 90 people in Calgary overdosed on the drug in 2015. In Southern California, a home-operated drug lab with six pill presses was uncovered by federal agents; each machine was capable of producing thousands of pills an hour.
Overdoses involving fentanyl have greatly contributed to the havoc caused by the opioid epidemic. In New Hampshire, two thirds of the fatal drug overdoses involved fentanyl, and most do not know that they are taking fentanyl. In 2017, a cluster of fentanyl overdoses in Florida was found to be caused by street sales of fentanyl pills sold as Xanax. According to the DEA, one kg of fentanyl can be bought in China for $3,000 to $5,000, and then smuggled into the United States by mail or Mexican drug cartels to generate over $1.5 million in revenue. The profitability of this drug has led dealers to adulterate other drugs with fentanyl without the knowledge of the drug user.
A "pill mill" is an clinic that dispenses narcotics to patients without a legitimate medical purpose. This is done at clinics and doctors offices, and the doctors will go through checkups extremely quickly to prescribe painkillers. These clinics will often charge an office fee of 200 to 400 dollars and can see up to 60 patients a day, which is very profitable for the clinic. These pill mills are also large suppliers of the illegal painkiller black markets on the streets. Dealers may hire people to go to pill mills to get painkiller prescriptions. There have been attempts recently to shut down pill mills. 250 pill mills in Florida were shut down in 2015. Florida clinics also are no longer allowed to dispense painkillers directly from their clinics which has helped reduce the distribution of prescription opiates.
A Pennsylvania doctor was charged with the deaths of five people after prescribing nearly 3 million pills in a 19-month period without proper patient examinations.
As the number of opioid prescriptions rose, drug cartels began flooding the U.S. with heroin from Mexico. For many opioid users, heroin was cheaper, more potent, and often easier to acquire than prescription medications. According to the CDC, tighter prescription policies by doctors did not necessarily lead to this increased heroin use. The main suppliers of heroin to the U.S. have been Mexican transnational criminal organizations. From 2005–2009, Mexican heroin production increased by over 600%, from an estimated 8 metric tons in 2005 to 50 metric tons in 2009. Between 2010 and 2014, the amount seized at the border more than doubled. According to the DEA, smugglers and distributors "profit primarily by putting drugs on the street and have become crucial to the Mexican cartels.":3
Illicit fentanyl is commonly made in Mexico and trafficked by cartels. North America’s dominant trafficking group is Mexico’s Sinaloa cartel, which has been linked to 80 percent of the fentanyl seized in New York.
When people continue to use opioids beyond what a doctor prescribes, whether to minimize pain or to enjoy the euphoric feelings, it can mark the beginning stages of an opiate addiction, with a tolerance developing and eventually leading to dependence, when a person relies on the drug to prevent withdrawal symptoms.
What the U.S. Surgeon General dubbed "The Opioid Crisis" likely began with over-prescription of powerful opioid pain relievers in the 1990s, which led to them becoming the most prescribed class of medications in the United States. As of 2016[update] more than 289 million prescriptions were written for opioid drugs per year.:43In the late 1990s, around 100 million people or a third of the U.S. population was estimated to be affected by chronic pain. This led to a push by drug companies and the federal government to expand the use of painkilling opioids. Between 1991 and 2011, painkiller prescriptions in the U.S. tripled from 76 million to 219 million per year. The most commonly prescribed opioids have been oxycodone (OxyContin and Percocet) and hydrocodone (Vicodin). With the increase in volume, the potency of opioids also increased. By 2002, one in six drug users were being prescribed drugs more powerful than morphine; by 2012, the ratio had doubled to one-in-three.
Furthermore, the structure of the US healthcare system, in which most people are required to get their own insurance in the absence of universal healthcare, favors prescribing drugs over expensive therapies. According to Professor Judith Feinberg from the West Virginia University School of Medicine, "most insurance, especially for poor people, won't pay for anything but a pill". As a consequence, prescription rates for opioids in the US are 40 percent higher than the rate in other developed countries such as Germany or Canada.
Despite the increased use of painkillers, there has been no change in the amount of pain reported in the U.S. This has led to differing medical opinions, with some noting that there is little evidence that opioids are effective for chronic pain not caused by cancer.
The Ensuring Patient Access and Effective Drug Enforcement Act, which was signed into law by President Obama on April 19, 2016, decreased the DEA's ability to intervene in the opioid crisis by modifying the Controlled Substances Act to require the DEA to prove "imminent danger to the public health and safety" before seizing shipments of controlled substances.
Effects of the opioid epidemic are multifactorial. The high death rate by overdose, the spread of communicable diseases, and the economic burden are major issues caused by the epidemic.
The opioid epidemic has since emerged as one of the worst drug crises in American history: more than 33,000 people died from overdoses in 2015, nearly equal to the number of deaths from car crashes, with deaths from heroin alone more than from gun homicides. It has also left thousands of children suddenly in need of foster care after their parents have died from an overdose.
In Alberta, a 2017 report stated that emergency department visits as a result of opiate overdose rose 1000% in the past five years.
In 2016, a study estimated that prescription opioid overdoes, abuse and dependence in the United States in 2013 cost was approximately $78.5 billion. Most of which was attributed to health care and criminal justice spending, along with lost productivity. However, in two years, statistics show significantly larger estimate because the epidemic has worsened with overdose and with deaths doubling in the past decade. White House stated on November 20, 2017, in 2015 alone, the opioid epidemic cost the United States an estimated $504 billion.
Spread of disease by drug users has also been an issue. Rates of hepatitis B and C diagnosis tripled over five years. The most effective medications to cure hepatitis C cost around $100,000 for a six-month course. Outbreaks of HIV among drug users have been reported in cities like Austin, Indiana, where 200 new cases were diagnosed.
In the U.S., addiction and overdose victims are mostly white or Native American and working-class. One physician conjectured that this may be due to doctors being less likely to prescribe opiates to black patients because of past drug abuse stereotypes.
In America, those living in rural areas of the country have been the hardest hit as a percentage of the national population, Canada is similarly affected, with 90% of cities with the highest hospitalization rates having a population below 225,000. Western Canada has an overdose rate nearly 10 times that of the eastern provinces.
Prescription drug abuse has been increasing in teenagers, especially as 12- to 17-year-olds were one-third of all new abusers of prescription drugs in 2006. Teens abuse prescription drugs more than any illicit drug except marijuana, more than cocaine, heroin, and methamphetamine combined, per the Office of National Drug Control Policy’s 2008 Report Prescription for Danger. Deaths from overdose of heroin affect a younger demographic than deaths from other opiates. The Canadian Institute for Health Information found that while overall, a third of overdoses were intentional, among those ages 15–24, nearly half were intentional.
State-to-State Variability: Prescribing rates for opioids varies differently across the states. In 2012, healthcare providers in the highest-prescribing state wrote almost three times as many opioid prescriptions per person as those in the lowest prescribing state. However, Health issues that cause people pain do not vary much from place to place and do not explain this variability in prescribing.
There has been a difference in the number of opioid prescriptions written by doctors in different states. In Hawaii, doctors wrote about 52 prescriptions for every 100 people, whereas in Alabama, they wrote almost 143 prescriptions per 100 people. Researchers suspect that the variation results from a lack of consensus among doctors in different states about how much pain medication to prescribe. A higher rate of prescription drug use does not lead to better health outcomes or patient satisfaction, according to studies.
|State||Opioid prescriptions written||Rank|
|District of Columbia||85.7||23|
Approximately 80 percent of the global pharmaceutical opioid supply is consumed in the United States.
It has also become a serious problem outside the U.S., mostly among young adults. The concern not only relates to the drugs themselves, but to the fact that in many countries doctors are less trained about drug addiction, both about its causes or treatment. According to an epidemiologist at Columbia University: "Once pharmaceuticals start targeting other countries and make people feel like opioids are safe, we might see a spike [in opioid abuse]. It worked here. Why wouldn’t it work elsewhere?" 
The majority of deaths worldwide from overdoses were from either medically prescribed opioids or illegal heroin. In Europe, prescription opioids accounted for three-quarters of overdose deaths among those between ages 15 and 39. Some worry that the epidemic could become a worldwide pandemic if not curtailed. Prescription drug abuse among teenagers in Canada, Australia, and Europe were at rates comparable to U.S. teenagers. In Lebanon and Saudi Arabia, and in parts of China, surveys found that one in ten students had used prescription painkillers for non-medical purposes. Similar high rates of non-medical use were found among the young throughout Europe, including Spain and the United Kingdom.
From January to August 2017, there were 60 fatal overdoses of fentanyl in the UK.
In 2010, the US government began cracking down on pharmacists and doctors who were over-prescribing opioid painkillers. An unintended consequence of this was that those addicted to prescription opiates turned to heroin, a significantly more potent but cheaper opioid, as a substitute. A 2017 survey in Utah of heroin users found about 80 percent started with prescription drugs.
In 2010, the Controlled Substances Act was amended with the Secure and Responsible Drug Disposal Act which allows pharmacies to accept controlled substances from households or long-term care facilities in their drug disposal programs or "take-back" programs.
In 2011, the federal government released a white paper describing the administration's plan to deal with the crisis. Its concerns have been echoed by numerous medical and government advisory groups around the world. In July 2016, President Barack Obama signed into law the Comprehensive Addiction and Recovery Act, which expands opioid addiction treatment with buprenorphine and authorizes millions of dollars in funding for opioid research and treatment.
In 2016, the U.S. Surgeon General listed statistics which describe the extent of the problem. The House and Senate passed the Ensuring Patient Access and Effective Drug Enforcement Act which was signed into law by President Obama on April 19, 2016, and may have decreased the DEA's ability to intervene in the opioid crisis. In December 2016, the 21st Century Cures Act, which includes $1 billion in state grants to fight the opioid epidemic, was passed by Congress by a wide bipartisan majority (94-5 in the Senate, 392-26 in the House of Representatives), and was signed into law by President Obama.
As of March 2017, President Donald Trump appointed a commission on the epidemic, chaired by Governor Chris Christie of New Jersey. On August 10, 2017, President Trump agreed with his Commission's report released few weeks earlier and declared the country's opioid crisis a "national emergency." Trump nominated Representative Tom Marino to be director of the Office of National Drug Control Policy, or "drug czar", however, on Oct. 17, 2017, Marino withdrew his nomination after it was reported that his relationship with the drug industry might be a conflict of interest. In July 2017, FDA commissioner Dr Scott Gottlieb stated that for the first time, pharmacists, nurses, and physicians, would have training made available on appropriate prescribing of opioid medicines, because opioid addiction had become the "FDA's biggest crisis".
In April 2017, the Department of Health and Human Services announced their "Opioid Strategy" consisting of five aims:
SAMHSA administers the Opioid State Targeted Response grants, a two-year program authorized by the 21st Century Cures Act which provided $485 million to states and U.S. territories in the fiscal year 2017 for the purpose of preventing and combatting opioid misuse and addiction.
In July 2016, governors from 45 U.S. states and three territories entered into a formal "Compact to Fight Opioid Addiction." They agreed that collective action would be needed to end the opioid crisis, and they would coordinate their responses across all levels of government and the private sector, including opioid manufacturers and doctors.
In March 2017, several states issues responses to the opioid crisis. The Governor of Maryland declared a State of Emergency to combat the rapid increase in overdoses by increasing and speeding up coordination between the state and local jurisdictions. In 2016, about 2,000 people in the state had died from opioid overdoses. Delaware, which has the 12th-highest overdose death rate in the U.S., introduced bills to both limit doctors' ability to over-prescribe painkillers and improve access to treatment. In 2015, 228 people had died from overdose, which increased 35%—to 308—in 2016. A similar plan was created in Michigan, which introduced the Michigan Automated Prescription System (MAPS), allowing doctors to check when and what painkillers have already been prescribed to a patient, and thereby help keep addicts from switching doctors to receive drugs. In Maine, new laws were imposed which capped the maximum daily strength of prescribed opioids and which limited prescriptions to seven days.
During the 2017 General Session of the Utah Legislature, Rep. Edward H. Redd and Sen. Todd Weiler proposed amendments to Utah's involuntary commitment statutes by trying to pass H.B. 299 into law which would allow relatives to petition a court to mandate substance-abuse treatment for adults.
In West Virginia, which leads the nation in overdose deaths per capita, lawsuits seek to declare drug distribution companies a "public nuisance" in an effort to place accountability upon the drug industry for the costs associated with the epidemic. In February 2017, officials in Everett, Washington filed a lawsuit against the Purdue Pharma, the manufacturer of OxyContin, for negligence by allowing drugs to be illegally trafficked to residents and failing to prevent it. The city wants the company to pay the costs of handling the crisis.
In 2016, the CDC published its "Guideline for Prescribing Opioids for Chronic Pain", recommending opioids only be used when benefits for pain and function are expected to outweigh risks, and then used at the lowest effective dosage, with avoidance of concurrent opioid and benzodiazepine use whenever possible. Silvia Martins, an epidemiologist at Columbia University, has suggested getting out more information about the risks:
The greater “social acceptance” for using these medications (versus illegal substances) and the misconception that they are “safe” may be contributing factors to their misuse. Hence, a major target for intervention is the general public, including parents and youth, who must be better informed about the negative consequences of sharing with others medications prescribed for their own ailments. Equally important is the improved training of medical practitioners and their staff to better recognize patients at potential risk of developing nonmedical use, and to consider potential alternative treatments as well as closely monitor the medications they dispense to these patients.
As of April 2017, prescription drug monitoring programs (PDMPs) exist in every state. A person on opioids for more than three months has a 15-fold (1,500%) greater chance of becoming addicted. PDMPs allow pharmacists and prescribers to access patients’ prescription histories to identify suspicious use. However, a survey of US physicians published in 2015 found only 53% of doctors used these programs, while 22% were not aware these programs were available. The Centers for Disease Control and Prevention (CDC) was tasked with establishing and publishing a new guideline, and was heavily lobbied.
Media coverage has largely focused on law-enforcement solutions to the epidemic, which portray the issue as criminal rather than medical. There has been differential reporting on how white suburban or rural addicts of opioids are portrayed compared to black and Hispanic urban addicts, often of heroin, reinforcing stereotypes of drug users and drug-using offenders. In newspapers, white addicts' stories are often given more space, allowing for a longer backstory explaining how they became addicted, and what potential they had before using drugs. Black and Hispanic addicts are more likely to be dehumanized, portrayed criminally, and mentioned more briefly. In early 2016 the national desk of the Washington Post began an investigation with assistance from the fired DEA regulator, Joseph Razzazzisi, on the rapidly increasing numbers of opioid related deaths.
While media coverage has focused more heavily on overdoses among whites, use among African, Hispanic and Native Americans has increased at similar rates. Deaths by overdose among white, black, and Native Americans increased by 200-300% from 2010-2014. During this time period, overdoses among Hispanics increased 140%, and the data available on overdoses by Asians was not comprehensive enough to draw a conclusion.
The opioid epidemic is often discussed in terms of prevention, but helping those who are already addicts is talked about less frequently. Opioid dependence can lead to a number of consequences like contraction of HIV and overdose. For addicts who wish to treat their addiction, there are two classes of treatment options available: medical and behavioral. Neither is guaranteed to successfully treat opioid addiction. Which, or which combination, is most effective varies from person to person.
These treatments are doctor-prescribed and -regulated, but differ in their treatment mechanism. Popular treatments include kratom,naloxone, methadone, and buprenorphine, which are more effective when combined with a form of behavioral treatment.
Methadone has been used for opioid dependence since 1964, and studied the most of the pharmacological treatment options. It is a synthetic long acting opioid, so it can replace multiple heroin uses by being taken once daily. It works by binding to the opioid receptors in the brain and spinal cord, activating them, reducing withdrawal symptoms and cravings while suppressing the "high" that other opioids can elicit. The decrease in withdrawal symptoms and cravings allow the user to slowly taper off the drug in a controlled manner, decreasing the likelihood of relapse. It is not accessible to all addicts. It is a regulated substance, and requires that each dose be picked up from a methadone clinic daily. This can be inconvenient as some patients are unable to travel to a clinic, or avoid the stigma associated with drug addiction.
Naloxone can be used as a rescue medication for opioid overdose or as a preventative measure for those wanting to stop using opiates. It is an opioid antagonist, meaning it binds to opioid receptors, which prevents them from being activated by opiates. It binds more strongly than other drugs, so that when someone is overdosing on opioids, naloxone can be administered, allowing it to take the place of the opioid drug in the person's receptors, turning them off. This blocks the effect of the receptors.
Many states have made Narcan available for purchase without a prescription. Additionally, peace officers in many districts have begun carrying Narcan on a routine basis.
Vivitrol is an long-lasting injectable form of naloxone that blocks the effects of opiates for four weeks. This eliminates the need to remember to take narcan on a daily basis. Naloxone is sometimes administered with other drugs such as buprenorphine, as a way to taper off buprenorphine over time.
Buprenorphine is used similarly to methadone, with some doctors recommending it as the best solution for medication-assisted treatment to help people reduce or quit their use of heroin or other opiates. It is claimed to be safer and less regulated than methadone, with month-long prescriptions allowed. It is also said to eliminate opiate withdrawal symptoms and cravings in many patients without inducing euphoria. Probuphine is an implantable form of buprenorphine lasting six months.
Unlike methadone treatment, which must be performed in a highly structured clinic, buprenorphine, according to SAMHSA, can be prescribed or dispensed in physician offices. Patients can thereby receive a full year of treatment for a fraction of the cost of detox programs.
It is less effective to use behavioral treatment without medical treatment during initial detoxification. It has similarly been shown that medical treatments tend to get better results when accompanied by behavioral treatment. Popular behavioral treatment options include group or individual therapy, residential treatment centers, and Twelve-step programs such as Narcotics Anonymous.
North America's first "safe injection site" opened in Vancouver. Rather than try to treat to prevent people from using drugs, these sites are intended to allow addicts to use drugs in an environment where help is immediately available in the event of an overdose. Health Canada has licensed 16 safe injection sites in the country. In Canada, about half of overdoses resulting in hospitalization were accidental, while a third were deliberate overdoses.