He was ten years old when he first became interested in being a DJ. He told author Paul Stenning, "At summer time block parties I wouldn't be the one dancing, I was sat where the DJ was set up, watching him. Even when I would go to other block parties in other neighborhoods I was still infatuated with the DJ. He was the guy that played music that everyone in the neighborhood loved. You might not have known his face, you might not have known his name but he was the guy that made everyone move."
When Smith branched out into television with the sitcomThe Fresh Prince of Bel-Air, Jazzy Jeff played a recurring character named Jazz, Smith's best friend on the show. In the early seasons, the two characters always greeted each other with their signature handshake (swinging mid-five, point-back, snap with both characters saying "Pssh!"). A recurring joke throughout the show's run involved the character being physically ejected from the house by Uncle Phil (James Avery), using the same footage for comedic effect.
Hamburg, Germany 2002
One of the first records DJ Jazzy Jeff ever appeared on was with The Korner Boyz (Street Artz Records) "Bust The Move and The Soga of Roxanne", which featured legendary Philadelphia rapper, MC Parry P and Grand Tone. The Instrumental was called "Jazzy Jeff Scratch" (1985). DJ Jazzy Jeff along with DJ Cash Money is cred with making the transformer scratch famous.
Some songs by Smith were produced by Townes (including “Here He Comes"), and he has performed on some songs by Smith such as "So Fresh" and "Potnas." In addition, he appeared in several of Smith's music videos such as "Will2K" and "Freakin' It". On some occasions, he made appearances with Smith at live concerts, producing DJ scratches. On July 2, 2005, DJ Jazzy Jeff performed with Smith at the Live 8 concert in Philadelphia. Moreover, Smith acknowledges him in his music such as "Comin' To The Stage" from the album Lost and Found and "Potnas" from his album Willennium.
His 2007 release The Return of the Magnificent featured numerous collaborations with old school and new school artists including CL Smooth, Big Daddy Kane, Pos from De La Soul, Method Man, Peedi Peedi (a remake of Brand New Funk), Rhymefest, and Raheem DeVaughn. In 2007, he appeared with Rhymefest in a video directed by Konee Rok, in which he makes music in his home recording studio with Rhymefest.
In 2008, Townes performed with Smith at the premiere of the latter's 2008 film Hancock.
In 2009, he made a mixtape titled He's the King...I'm the DJ in honor of the late entertainer Michael Jackson. Townes was featured in the video game DJ Hero as a playable character. He also has some original mixes in the game.
In 2010, DJ Jazzy Jeff and Mick (formerly known as Mick Boogie) teamed up to release "Summertime: The Mixtape" series. The mixes are released every summer. 
In 2013, DJ Jazzy Jeff performed with Will Smith on the Graham Norton Show. Also that same year, DJ Jazzy Jeff released Vinyl Destination, a web series documenting his hundred plus DJ shows from all around the world. He also appeared as the lead interview in Paul Stenning's book, Success - By Those Who've Made It.