Protein B3GAT2 PDB 2d0j.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesB3GAT2, GLCATS, beta-1,3-glucuronyltransferase 2
External IDsOMIM: 607497 MGI: 2389490 HomoloGene: 50574 GeneCards: B3GAT2
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 70.86 – 70.96 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 is an enzyme that in humans is encoded by the B3GAT2 gene.[4][5]

The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.[5]

Use of HNK-1 Antibody for Neural Crest Research[]

Antibodies raised against the HNK-1 epitope have played a large role in studies of the neural crest, especially in the avian embryo.[6] The first antibody raised against this epitope was NC-1,[7] which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112309 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope". Gene. 296 (1–2): 29–36. doi:10.1016/S0378-1119(02)00840-5. PMID 12383500.
  5. ^ a b "Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)".
  6. ^ Bronner-Fraser M (May 1986). "Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1". Dev. Biol. 115 (1): 44–55. doi:10.1016/0012-1606(86)90226-5. PMID 3516760.
  7. ^ Vincent M, Thiery JP (June 1984). "A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system". Dev. Biol. 103 (2): 468–81. doi:10.1016/0012-1606(84)90334-8. PMID 6202575.

External links[]

Further reading[]