10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase

Taxoid 14beta-hydroxylase
Identifiers
EC number1.14.13.146
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Taxoid 14beta-hydroxylase (EC 1.14.13.146) is an enzyme with systematic name 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O

Taxoid 14beta-hydroxylase requires cytochrome P450.

References[]

  1. ^ Jennewein S, Rithner CD, Williams RM, Croteau R (May 2003). "Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase". Archives of Biochemistry and Biophysics. 413 (2): 262–70. doi:10.1016/s0003-9861(03)00090-0. PMID 12729625.

External links[]