10R-DOX

Linoleate 10R-lipoxygenase
Identifiers
EC number1.13.11.62
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Linoleate 10R-lipoxygenase (EC 1.13.11.62, 10R-DOX, (10R)-dioxygenase, 10R-dioxygenase) is an enzyme with systematic name linoleate:oxygen (10R)-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

linoleate + O2 (8E,10R,12Z)-10-hydroperoxy-8,12-octadecadienoate

Linoleate 10R-lipoxygenase is involved in biosynthesis of oxylipins.

References[]

  1. ^ Garscha U, Oliw EH (May 2009). "Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity". The Journal of Biological Chemistry. 284 (20): 13755–65. doi:10.1074/jbc.M808665200. PMC 2679477. PMID 19289462.
  2. ^ Jernerén F, Garscha U, Hoffmann I, Hamberg M, Oliw EH (April 2010). "Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1801 (4): 503–7. doi:10.1016/j.bbalip.2009.12.012. PMID 20045744.

External links[]