|Preferred IUPAC name
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||473.44 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
10-Formyltetrahydrofolate (10-CHO-THF) is a form of tetrahydrofolate that acts as a donor of formyl groups in anabolism. In these reactions 10-CHO-THF is used as a substrate in formyltransferase reactions.
Note of clarification on where the aldehyde (formyl) group is: Look at the middle portion of the compound here, you will see you a nitrogen attached to the phenyl aromatic ring, and attached to that nitrogen you will see the carbon portion of interest (looks like a carbonyl C=O), and note that hydrogens are sometimes not shown in order to conserve space but should be implied. In this case, the hydrogen is not shown explicitly here but just note that the hydrogen can be drawn for clarification that it is an aldehyde present there (formyl group specifically, CHO, one carbon aldehyde).
Two equivalents of 10-CHO-THF are required in purine biosynthesis through the pentose phosphate pathway, where 10-CHO-THF is a substrate for phosphoribosylaminoimidazolecarboxamide formyltransferase.
In the second step 5,10-methenyltetrahydrofolate undergoes hydrolysis:
The latter is equivalently written:
10-CHO-THF is also produced by the reaction
This reaction is catalyzed by formate-tetrahydrofolate ligase.