1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase
EC no.
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC, phosphatidylinositol-4,5-bisphosphate 4-phosphatase I, phosphatidylinositol-4,5-bisphosphate 4-phosphatase II, type I PtdIns-4,5-P2 4-Ptase, type II PtdIns-4,5-P2 4-Ptase, IpgD, PtdIns-4,5-P2 4-phosphatase type I, PtdIns-4,5-P2 4-phosphatase type II, type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase, type 1 4-phosphatase) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate

This enzyme participates in one of the mammalian pathways for degradation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].


  1. ^ Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B (October 2002). "Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology". The EMBO Journal. 21 (19): 5069–78. doi:10.1093/emboj/cdf522. PMC 129044. PMID 12356723.
  2. ^ Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW (December 2005). "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases". Proceedings of the National Academy of Sciences of the United States of America. 102 (52): 18854–9. doi:10.1073/pnas.0509740102. PMC 1323219. PMID 16365287.
  3. ^ Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW (October 2007). "Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis". Proceedings of the National Academy of Sciences of the United States of America. 104 (43): 16834–9. doi:10.1073/pnas.0708189104. PMC 2040409. PMID 17940011.
  4. ^ Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S (April 2007). "Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase". The Journal of General Physiology. 129 (4): 267–83. doi:10.1085/jgp.200609656. PMC 2151621. PMID 17389247.

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