1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Identifiers
EC no.3.1.3.67
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (EC 3.1.3.67) is an enzyme that catalyzes the chemical reaction

phosphatidylinositol 3,4,5-trisphosphate + H2O phosphatidylinositol 4,5-bisphosphate + phosphate

Thus, the two substrates of this enzyme are phosphatidylinositol 3,4,5-trisphosphate and H2O, whereas its two products are phosphatidylinositol 4,5-bisphosphate and phosphate.

This enzyme class belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase. Other names in common use include PTEN,[citation needed] MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. PTEN also refers to a member of the class, phosphatase and tensin homolog.[citation needed] This enzyme class participates in 10 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, p53 signaling pathway, focal adhesion, tight junction, endometrial cancer, glioma, prostate cancer, melanoma, and small cell lung cancer. It employs one cofactor, magnesium.

References[]