1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3

PLCD3
Identifiers
AliasesPLCD3, PLC-delta-3, phospholipase C delta 3
External IDsOMIM: 608795 MGI: 107451 HomoloGene: 14858 GeneCards: PLCD3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_133373

NM_152813
NM_001361706

RefSeq (protein)

NP_588614

NP_690026
NP_001348635

Location (UCSC)Chr 17: 45.11 – 45.13 MbChr 11: 103.07 – 103.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.[5][6][7]

Function[]

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca2+ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.[7]

References[]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161714 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020937 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 209–10. doi:10.1159/000015469. PMID 10702670. S2CID 87171791.
  6. ^ Ghosh S, Pawelczyk T, Lowenstein JM (Mar 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expression and Purification. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
  7. ^ a b "Entrez Gene: PLCD3 phospholipase C, delta 3".

Further reading[]