Preferred IUPAC name
Other names
n-Octacosanol; Octacosyl alcohol; Octanosol; Montanyl alcohol; Cluytyl alcohol
3D model (JSmol)
ECHA InfoCard 100.008.348 Edit this at Wikidata
MeSH 1-octacosanol
  • InChI=1S/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3 checkY
  • InChI=1/C28H58O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29/h29H,2-28H2,1H3
Molar mass 410.771 g·mol−1
Melting point 83 °C (181 °F; 356 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

1-Octacosanol[pronunciation?] (also known as n-octacosanol, octacosyl alcohol, cluytyl[pronunciation?] alcohol, montanyl[pronunciation?] alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent.[1] Octacosanol also occurs in wheat germ.[2]


Octacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform.

Biological effects[]

Octacosanol is the main component in the mixture policosanol.[3] Octacosanol has been subject to preliminary study for its potential benefit for patients with Parkinson's disease.[4][5] Studies have also found that octacosanol may inhibit the production of cholesterol.[3] In mice, octacosanol reduces stress and restores stress-affected sleep back to normal.[6]


  1. ^ EA Baker (1982) Chemistry and morphology of plant epicuticular waxes. pp. 139–165. In "The Plant Cuticle". ed by DF Cutler, KL Alvin and CE Price. Academic Press, London. ISBN 0-12-199920-3
  2. ^ "Octacosanol". Natural Products (Professional). drugs.com. Archived from the original on 3 June 2009. Retrieved 9 July 2009. isolated from wheat germ oil or other plants
  3. ^ a b Taylor, Johanna C; Rapport, Lisa; Lockwood, G.Brian (2003). "Octacosanol in human health". Nutrition. 19 (2): 192–5. doi:10.1016/S0899-9007(02)00869-9. PMID 12591561.
  4. ^ Snider, SR (1984). "Octacosanol in parkinsonism". Annals of Neurology. 16 (6): 723. doi:10.1002/ana.410160615. PMID 6395790. S2CID 43313071.
  5. ^ Wang, T; Liu, YY; Wang, X; Yang, N; Zhu, HB; Zuo, PP (2010). "Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling". Acta Pharmacologica Sinica. 31 (7): 765–74. doi:10.1038/aps.2010.69. PMC 4007727. PMID 20581854.
  6. ^ Kaushik, MK; Aritake, K; Takeuchi, A; Yanagisawa, M; Urade, Y (21 August 2017). "Octacosanol restores stress-affected sleep in mice by alleviating stress". Scientific Reports. 7 (1): 8892. Bibcode:2017NatSR...7.8892K. doi:10.1038/s41598-017-08874-2. PMC 5566941. PMID 28827687.