1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase

2,6-dihydroxypseudooxynicotine hydrolase
Identifiers
EC no.3.7.1.19
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

2,6-dihydroxypseudooxynicotine hydrolase (EC 3.7.1.19) is an enzyme with systematic name 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase.[1][2] This enzyme catalyses the following chemical reaction

1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O 2,6-dihydroxypyridine + 4-methylaminobutanoate

The enzyme is present in the soil bacterium Arthrobacter nicotinovorans.

References[]

  1. ^ Gherna RL, Richardson SH, Rittenberg SC (September 1965). "The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine". The Journal of Biological Chemistry. 240 (9): 3669–74. PMID 5835946.
  2. ^ Sachelaru P, Schiltz E, Igloi GL, Brandsch R (December 2005). "An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans". Journal of Bacteriology. 187 (24): 8516–9. doi:10.1128/jb.187.24.8516-8519.2005. PMC 1317030. PMID 16321959.

External links[]