|Preferred IUPAC name
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||201.889 g·mol−1|
|Density||1.989 g mL−1|
|Melting point||−34.20 °C; −29.56 °F; 238.95 K|
|Boiling point||167 °C; 332 °F; 440 K|
|11 μmol Pa−1 kg−1|
Refractive index (nD)
Heat capacity (C)
|163.7 J K mol−1|
|GHS Signal word||Warning|
|H226, H302, H315, H411|
|Flash point||56 °C (133 °F; 329 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
|315 mg kg−1 (oral, rat)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
1,3-Dibromopropane is an organobromine compound with the formula (CH2)3Br2. It is a colorless liquid with sweet odor. It is used in organic synthesis to form C3-bridged compounds such as through C-N coupling reactions.
Metabolism of 1,3-dibromopropane was examined in 1981. The examination was done by orally administering 1,3-dibromopropane to rats and collection results 24hours after administration. Results were obtained from three sources: urine, faeces, and expired air. Upon analysis of the urinary results, researchers discovered the formation of metabolite, N-acetyl-S-(1-bromo-3-propyl)-cysteine and the decline in the GSH content of the liver of the rats. This led to the assumption that 1,3-dibromopropane could have reacted with GSH after administration and gave rise to 1-bromo-3-propyl-S-glutathione, which ultimately form the urinary metabolite. Moreover, due to little radioactivity observed from feces and the confirmation from maintained blood levels of radioactivity proved the occurrence of biliary excretion of sulfur-containing metabolites and enterohepatic cycling.