Theacrine has demonstrated clinical safety and non-habituating effects in healthy humans over 8 weeks of daily use at up to 300 mg/day. Moreover, there was no evidence of tachyphylaxis that is typical of neuroactive agents such as caffeine and other stimulants.
In animal studies, theacrine has an LD50 of 810 mg/kg, compared to 265 mg/kg for caffeine.
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