1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase

Diacylglycerol diphosphate phosphatase
EC no.
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Diacylglycerol diphosphate phosphatase (EC, DGPP phosphatase, DGPP phosphohydrolase, DPP1, DPPL1, DPPL2, PAP2, pyrophosphate phosphatase) is an enzyme with systematic name 1,2-diacyl-sn-glycerol 3-phosphate phosphohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

1,2-diacyl-sn-glycerol 3-diphosphate + H2O 1,2-diacyl-sn-glycerol 3-phosphate + phosphate

The phosphatase activity of this enzyme is Mg2+-independent.


  1. ^ Dillon DA, Wu WI, Riedel B, Wissing JB, Dowhan W, Carman GM (November 1996). "The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity". The Journal of Biological Chemistry. 271 (48): 30548–53. doi:10.1074/jbc.271.48.30548. PMID 8940025.
  2. ^ Dillon DA, Chen X, Zeimetz GM, Wu WI, Waggoner DW, Dewald J, Brindley DN, Carman GM (April 1997). "Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity". The Journal of Biological Chemistry. 272 (16): 10361–6. doi:10.1074/jbc.272.16.10361. PMID 9099673.
  3. ^ Wu WI, Liu Y, Riedel B, Wissing JB, Fischl AS, Carman GM (January 1996). "Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae". The Journal of Biological Chemistry. 271 (4): 1868–76. doi:10.1074/jbc.271.4.1868. PMID 8567632.
  4. ^ Oshiro J, Han GS, Carman GM (November 2003). "Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1635 (1): 1–9. doi:10.1016/j.bbalip.2003.10.002. PMID 14642771.
  5. ^ Carman GM (September 1997). "Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1348 (1–2): 45–55. doi:10.1016/s0005-2760(97)00095-7. PMID 9370315.
  6. ^ Han GS, Johnston CN, Chen X, Athenstaedt K, Daum G, Carman GM (March 2001). "Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc". The Journal of Biological Chemistry. 276 (13): 10126–33. doi:10.1074/jbc.m011421200. PMID 11139591.

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