1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase

Mannosyl-oligosaccharide 1,2-alpha-mannosidase
EC no.
CAS no.9068-25-1
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC, mannosidase 1A, mannosidase 1B, 1,2-alpha-mannosidase, exo-alpha-1,2-mannanase, mannose-9 processing alpha-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name 2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase.[1][2] This enzyme catalyses the following chemical reaction

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2

This enzyme is involved in the synthesis of glycoproteins.

Kifunensine is a potent inhibitor of mannosidase I.


  1. ^ Tabas I, Kornfeld S (November 1979). "Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides". The Journal of Biological Chemistry. 254 (22): 11655–63. PMID 500665.
  2. ^ Tulsiani DR, Hubbard SC, Robbins PW, Touster O (April 1982). "alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. PMID 7061502.

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