**0O** (zero O) or **0-O** may refer to:

- 0o, 0_o, and 0.o, a kaomoji emoticon that may refer to shocked, disturbed, or confused.
- 0-O, abbreviation for 0-operand instruction set
- 0o, or zero object, a mathematics term for a simultaneously initial and terminal object
- 0O, also ZO, an abbreviation for zero order
- Zero-order hold, model of the practical signal reconstruction done by a conventional digital-to-analog converter
- Zero order process (chemistry), a chemical reaction in which the rate of change of concentration is independent of the concentrations
- Zeroth-order logic, first-order logic without quantifiers
- Zero-order process (statistics), a sequence of random variables, each independent of the previous ones
- Zeroth-order approximation, an approximation of a function by a constant

- 0o, a prefix used in some programming languages to denote octal (base 8) integer literals

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