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|Place of origin||USA|
|Variants||.25-35 Ackley Improved, 6.5×52mmR|
|Parent case||.30-30 Winchester|
|Bullet diameter||.258 in (6.6 mm)|
|Neck diameter||.282 in (7.2 mm)|
|Shoulder diameter||.365 in (9.3 mm)|
|Base diameter||.422 in (10.7 mm)|
|Rim diameter||.506 in (12.9 mm)|
|Rim thickness||.063 in (1.6 mm)|
|Case length||2.043 in (51.9 mm)|
|Overall length||2.55 in (65 mm)|
|Rifling twist||1 in 8 in (200 mm)|
|Primer type||Large Rifle|
|Maximum pressure||44,000 psi (300 MPa)|
|Test barrel length: 24"|
Source(s): Hodgdon 
The .25-35 Winchester, or WCF (Winchester Center Fire) was introduced in 1895 by Winchester for the Winchester Model 1894 and Savage Model 99 lever action rifles. The case was based on the .30-30 cartridge.
Significantly more powerful than the .25-20 Winchester, the .25-35 WCF can be used to hunt small deer at 200 yards and medium-sized deer at 100 yards; however, some consider it better suited to small predators such as coyotes instead. As a matter of history, some hunters in Canada or the U.S. have used it on moose or elk; this is not advisable today. It was a popular round in the Winchester Model 1885 High Wall single-shot rifle. No production rifles had been made in .25-35 WCF since 1964 until 2005 when Winchester resumed chambering their Model 94 rifles in this cartridge. Winchester ammunition has kept the cartridge in production in the U.S.A.
The 6.5×52mmR is a European cartridge that is a close variant of the .25-35 Winchester. It should not be considered identical to the .25-35 Winchester and is not treated as such by the Commission Internationale Permanente pour l'Epreuve des Armes à Feu Portatives (CIP), which has released separate specifications for each cartridge. The 6.5x52mmR has its origins in Germany and was introduced by RWS and is chambered in many drilling and single-shot rifles. Any interchangeability between the two cartridges is solely dependent on individual chamber tolerances and should not be assumed.