Forming in 2001, The Acacia Strain was started by high school friends Vincent Bennett, Christopher Daniele, and Ben Abert. Looking to bring their current band Septic Orgasm to the next level of technicality, they brought in their mutual friend, Karrie Whitfield, and high school student Daniel "DL" Laskiewicz to play bass and guitar respectively. The band began playing local shows around Massachusetts and recorded their demo in 2001.
After DL received a shoulder injury while playing high school football, Bennett asked friend and current Blood Has Been Shed guitarist, Daniel Daponde, to fill in on guitar while DL healed from his injury. The group felt Daponde brought a heavier and more technical aspect to the band, so when DL returned they concluded Deponde to stay, thus forming the unusual three guitar lineup.
After countless local shows, including quite a few in Bennett mother's basement, the band was approached by Toby Dutkiewicz, who ran Devil's Head records, if they would join his label. The band agreed and recording for their debut album "...and Life is Very Long" began in 2002 at Zing recording studio in Westfield, Massachusetts with Adam Dutkiewicz and Jim Fogarty at the helm with Jim doing most of the tracking.
AllMusic characterizes the band's musical style as "utiliz[ing] a bone-crushing rhythm section, apocalyptic samples, and a unique triple-guitar assault to deliver their signature blend of hardcore punk, noise, death metal and doom metal." The site's review of Wormwood elaborates on the band's sound as "an inelegant and unstoppable juggernaut fueled by memories of the unchecked aggression unleashed on the world by the likes of Sepultura and Pantera."
Vocalist Vincent Bennett and drummer Kevin Boutot have both denied that The Acacia Strain is of the "deathcore genre," going as far as expressing dislike for the label.