Diagram illustrating genomics

The branches of science known informally as omics are various disciplines in biology whose names end in the suffix -omics, such as genomics, proteomics, metabolomics, metagenomics and transcriptomics. Omics aims at the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms.

The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively. The suffix -ome as used in molecular biology refers to a totality of some sort; it is an example of a "neo-suffix" formed by abstraction from various Greek terms in -ωμα, a sequence that does not form an identifiable suffix in Greek.

Functional genomics aims at identifying the functions of as many genes as possible of a given organism. It combines different -omics techniques such as transcriptomics and proteomics with saturated mutant collections.[1]


"Omicum": Building of the Estonian Biocentre which houses the Estonian Genome Centre and Institute of Molecular and Cell Biology at the University of Tartu in Tartu, Estonia.

The Oxford English Dictionary (OED) distinguishes three different fields of application for the -ome suffix:

  1. in medicine, forming nouns with the sense "swelling, tumour"
  2. in botany or zoology, forming nouns in the sense "a part of an animal or plant with a specified structure"
  3. in cellular and molecular biology, forming nouns with the sense "all constituents considered collectively"

The -ome suffix originated as a variant of -oma, and became productive in the last quarter of the 19th century. It originally appeared in terms like sclerome[2] or rhizome.[3] All of these terms derive from Greek words in -ωμα,[4] a sequence that is not a single suffix, but analyzable as -ω-μα, the -ω- belonging to the word stem (usually a verb) and the -μα being a genuine Greek suffix forming abstract nouns.

The OED suggests that its third definition originated as a back-formation from mitome,[5] Early attestations include biome (1916)[6] and genome (first coined as German Genom in 1920[7]).[8]

The association with chromosome in molecular biology is by false etymology. The word chromosome derives from the Greek stems χρωμ(ατ)- "colour" and σωμ(ατ)- "body".[8] While σωμα "body" genuinely contains the -μα suffix, the preceding -ω- is not a stem-forming suffix but part of the word's root. Because genome refers to the complete genetic makeup of an organism, a neo-suffix -ome suggested itself as referring to "wholeness" or "completion".[9]

Bioinformaticians and molecular biologists figured amongst the first scientists to apply the "-ome" suffix widely. Early advocates included bioinformaticians in Cambridge, UK, where there were many early bioinformatics labs such as the MRC centre, Sanger centre, and EBI (European Bioinformatics Institute). For example, the MRC centre carried out the first genome and proteome projects.

Kinds of omics studies[]



The epigenome is the supporting structure of genome, including protein and RNA binders, alternative DNA structures, and chemical modifications on DNA.


Lipidome is the entire complement of cellular lipids, including the modifications made to a particular set of lipids, produced by an organism or system.


Proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system.


Glycomics is the comprehensive study of the glycome i.e. sugars and carbohydrates.


Foodomics was defined in 2009 as "a discipline that studies the Food and Nutrition domains through the application and integration of advanced -omics technologies to improve consumer's well-being, health, and knowledge"


Transcriptome is the set of all RNA molecules, including mRNA, rRNA, tRNA, and other non-coding RNA, produced in one or a population of cells.


Nutrition, pharmacology, and toxicology[]


Inspired by foundational questions in evolutionary biology, a Harvard team around Jean-Baptiste Michel and Erez Lieberman Aiden created the American neologism culturomics for the application of big data collection and analysis to cultural studies.


A National Oceanic and Atmospheric Administration scientist using microbiomics to study marine ecosystems

Unrelated words in -omics[]

The word "comic" does not use the "omics" suffix; it derives from Greek "κωμ(ο)-" (merriment) + "-ικ(ο)-" (an adjectival suffix), rather than presenting a truncation of "σωμ(ατ)-".

Similarly, the word "economy" is assembled from Greek "οικ(ο)-" (household) + "νομ(ο)-" (law or custom), and "economic(s)" from "οικ(ο)-" + "νομ(ο)-" + "-ικ(ο)-". The suffix -omics is sometimes used to create names for schools of economics, such as Reaganomics.

Current usage[]

Many "omes" beyond the original "genome" have become useful and have been widely adopted by research scientists. "Proteomics" has become well-established as a term for studying proteins at a large scale. "Omes" can provide an easy shorthand to encapsulate a field; for example, an interactomics study is clearly recognisable as relating to large-scale analyses of gene-gene, protein-protein, or protein-ligand interactions. Researchers are rapidly taking up omes and omics, as shown by the explosion of the use of these terms in PubMed since the mid 1990s.[16]

See also[]


  1. ^ Holtorf, Hauke; Guitton, Marie-Christine; Reski, Ralf (2002). "Plant functional genomics". Naturwissenschaften. 89 (6): 235–249. Bibcode:2002NW.....89..235H. doi:10.1007/s00114-002-0321-3. PMID 12146788. S2CID 7768096.
  2. ^ "scleroma, n : Oxford English Dictionary". Retrieved 2011-04-25.
  3. ^ "rhizome, n : Oxford English Dictionary". Retrieved 2011-04-25.
  4. ^ "-oma, comb. form : Oxford English Dictionary". Retrieved 2011-04-25.
  5. ^ "Home : Oxford English Dictionary". Retrieved 2011-04-25.
  6. ^ "biome, n. : Oxford English Dictionary". Retrieved 2011-04-25.
  7. ^ Hans Winkler (1920). Verbreitung und Ursache der Parthenogenesis im Pflanzen - und Tierreiche. Verlag Fischer, Jena. p. 165. Ich schlage vor, für den haploiden Chromosomensatz, der im Verein mit dem zugehörigen Protoplasma die materielle Grundlage der systematischen Einheit darstellt den Ausdruck: das Genom zu verwenden ... " In English: " I propose the expression Genom for the haploid chromosome set, which, together with the pertinent protoplasm, specifies the material foundations of the species ...
  8. ^ a b Coleridge, H.; et alii. The Oxford English Dictionary
  9. ^ Liddell, H.G.; Scott, R.; et alii. A Greek-English Lexicon [1996]. (Search at Perseus Project.)
  10. ^ O'Connell, Mary J.; McNally, Alan; McInerney, James O. (2017-03-28). "Why prokaryotes have pangenomes" (PDF). Nature Microbiology. 2 (4): 17040. doi:10.1038/nmicrobiol.2017.40. ISSN 2058-5276. PMID 28350002. S2CID 19612970.
  11. ^ Tashiro, Satoshi; Lanctôt, Christian (2015-03-04). "The International Nucleome Consortium". Nucleus. 6 (2): 89–92. doi:10.1080/19491034.2015.1022703. PMC 4615172. PMID 25738524.
  12. ^ Cremer, Thomas; Cremer, Marion; Hübner, Barbara; Strickfaden, Hilmar; Smeets, Daniel; Popken, Jens; Sterr, Michael; Markaki, Yolanda; Rippe, Karsten (2015-10-07). "The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments". FEBS Letters. 589 (20PartA): 2931–2943. doi:10.1016/j.febslet.2015.05.037. ISSN 1873-3468. PMID 26028501. S2CID 10254118.
  13. ^ Cumpson, Peter; Fletcher, Ian; Sano, Naoko; Barlow, Anders (2016). "Rapid multivariate analysis of 3D ToF-SIMSdata: graphical processor units (GPUs) and low-discrepancy subsampling for large-scale principal component analysis". Surface and Interface Analysis. 48 (12): 1328. doi:10.1002/sia.6042.
  14. ^ Reiser, Michael (2009). "The ethomics era?". Nature Methods. 6 (6): 413–414. doi:10.1038/nmeth0609-413. PMID 19478800. S2CID 5151763.
  15. ^ Kazantzidis, Ioannis; Florez-Revuelta, Francisco; Dequidt, Mickael; Hill, Natasha; Nebel, Jean-Christophe (2018). "Vide-omics: A genomics-inspired paradigm for video analysis". Computer Vision and Image Understanding. 166: 28–40. doi:10.1016/j.cviu.2017.10.003.
  16. ^ "O M E S Page". bioinfo.mbb.yale.edu.

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