In genetics, rs1800955 (also written as C-521T and -521C/T) is a single nucleotide polymorphism (SNP).
It is located in the promoter region of the DRD4 gene.
This gene codes for the dopamine receptor D4.
Due to the dopamine hypothesis of schizophrenia the SNP has been investigated for link to schizophrenia, and it may be slightly associated with this disorder.
The SNP has been investigated with respect to novelty seeking, — a personality trait that may be measured with the Temperament and Character Inventory.
A 2008 meta-analysis indicates a possible association between novelty seeking and C-521T though rather small.
- ^ "Meta-Analysis of All Published Schizophrenia-Association Studies (Case-Control Only) rs1800955". Schizophrenia Research Forum. Retrieved 2008-09-05.
- ^ Y. Okuyama, H. Ishiguro, M. Nankai, H. Shibuya, A. Watanabe & T. Arinami (January 2000). "Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait". Molecular Psychiatry. 5 (1): 64–69. doi:10.1038/sj.mp.4000563. PMID 10673770.CS1 maint: multiple names: authors list (link)
- ^ Z. Ronai, A. Szekely, Z. Nemoda, K. Lakatos, J. Gervai, M. Staub & M. Sasvari-Szekely (January 2001). "Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene". Molecular Psychiatry. 6 (1): 35–38. doi:10.1038/sj.mp.4000832. PMID 11244482.CS1 maint: multiple names: authors list (link)
- ^ Marcus R. Munafo, Binnaz Yalcin, Saffron A. Willis-Owen & Jonathan Flint (January 2008). "Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data". Biological Psychiatry. 63 (2): 197–206. doi:10.1016/j.biopsych.2007.04.006. PMID 17574217.CS1 maint: multiple names: authors list (link)
- Table 4 from "The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes"