(R)-piperazine-2-carboxamide amidohydrolase

(R)-amidase
Identifiers
EC no.3.5.1.100
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

(R)-amidase (EC 3.5.1.100, R-stereospecific amidase, R-amidase) is an enzyme with systematic name (R)-piperazine-2-carboxamide amidohydrolase.[1] This enzyme catalyses the following chemical reaction

(1) (R)-piperazine-2-carboxamide + H2O (R)-piperazine-2-carboxylic acid + NH3
(2) beta-alaninamide + H2O beta-alanine + NH3

This enzyme also hydrolyses (R)-piperidine-3-carboxamide to (R)-piperidine-3-carboxylic acid and NH3.

References[]

  1. ^ Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y (April 2004). "A novel R-stereoselective amidase from Pseudomonas sp. MCI3434 acting on piperazine-2-tert-butylcarboxamide". European Journal of Biochemistry. 271 (8): 1580–90. CiteSeerX 10.1.1.547.2141. doi:10.1111/j.1432-1033.2004.04069.x. PMID 15066183.

External links[]