(R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase

Methanogen homoaconitase
Identifiers
EC no.4.2.1.114
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Methanogen homoaconitase (EC 4.2.1.114, methanogen HACN) is an enzyme with systematic name (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming).[1] This enzyme catalyses the following chemical reaction

(R)-2-hydroxybutane-1,2,4-tricarboxylate (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction)
(1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
(1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate

This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.

References[]

  1. ^ Drevland RM, Jia Y, Palmer DR, Graham DE (October 2008). "Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis". The Journal of Biological Chemistry. 283 (43): 28888–96. doi:10.1074/jbc.m802159200. PMC 2662002. PMID 18765671.

External links[]