(R)-2-hydroxy-acid:acceptor 2-oxidoreductase

D-2-hydroxy-acid dehydrogenase
Identifiers
EC no.1.1.99.6
CAS no.9028-83-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) is an enzyme that catalyzes the chemical reaction

(R)-lactate + acceptor pyruvate + reduced acceptor

Thus, the two substrates of this enzyme are (R)-lactate and acceptor, whereas its two products are pyruvate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-2-hydroxy-acid:acceptor 2-oxidoreductase. Other names in common use include D-2-hydroxy acid dehydrogenase, and (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase. It has 2 cofactors: FAD, and Zinc.

References[]