(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming)

9,12-octadecadienoate 8-hydroperoxide 8S-isomerase
Identifiers
EC number5.4.4.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

9,12-octadecadienoate 8-hydroperoxide 8S-isomerase (EC 5.4.4.6, 8-hydroperoxide isomerase, (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-7,8-dihydroxy-9,12-octadecadienoate-forming)) is an enzyme with systematic name (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase ((7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate

This enzyme contains heme.

References[]

  1. ^ Hamberg M, Zhang LY, Brodowsky ID, Oliw EH (February 1994). "Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions". Archives of Biochemistry and Biophysics. 309 (1): 77–80. doi:10.1006/abbi.1994.1087. PMID 8117115.
  2. ^ Su C, Sahlin M, Oliw EH (August 1998). "A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities". The Journal of Biological Chemistry. 273 (33): 20744–51. doi:10.1074/jbc.273.33.20744. PMID 9694817.
  3. ^ Su C, Oliw EH (June 1996). "Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein". The Journal of Biological Chemistry. 271 (24): 14112–8. doi:10.1074/jbc.271.24.14112. PMID 8662736.

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