(8E)-9-((1E,3E)-nona-1,3-dien-1-yloxy)non-8-enoate synthase

Colneleate synthase
EC no.
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Colneleate synthase (EC, 9-divinyl ether synthase, 9-DES, CYP74D, CYP74D1, CYP74 cytochrome P-450, DES1) is an enzyme with systematic name (8E)-9-((1E,3E)-nona-1,3-dien-1-yloxy)non-8-enoate synthase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoate (8E)-9-[(1E,3Z)-nona-1,3-dien-1-yloxy]non-8-enoate + H2O

This enzyme is a heme-thiolate protein (P450).


  1. ^ Stumpe M, Kandzia R, Göbel C, Rosahl S, Feussner I (November 2001). "A pathogen-inducible divinyl ether synthase (CYP74D) from elicitor-treated potato suspension cells". FEBS Letters. 507 (3): 371–6. doi:10.1016/s0014-5793(01)03019-8. PMID 11696374.
  2. ^ Itoh A, Howe GA (February 2001). "Molecular cloning of a divinyl ether synthase. Identification as a CYP74 cytochrome P-450". The Journal of Biological Chemistry. 276 (5): 3620–7. doi:10.1074/jbc.m008964200. PMID 11060314.
  3. ^ Fammartino A, Cardinale F, Göbel C, Mène-Saffrané L, Fournier J, Feussner I, Esquerré-Tugayé MT (January 2007). "Characterization of a divinyl ether biosynthetic pathway specifically associated with pathogenesis in tobacco". Plant Physiology. 143 (1): 378–88. doi:10.1104/pp.106.087304. PMC 1761965. PMID 17085514.
  4. ^ Hamberg M (February 2005). "Hidden stereospecificity in the biosynthesis of divinyl ether fatty acids". The FEBS Journal. 272 (3): 736–43. doi:10.1111/j.1742-4658.2004.04510.x. PMID 15670154.

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