(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase

ADP-dependent NAD(P)H-hydrate dehydratase
Identifiers
EC number4.2.1.136
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

ADP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.136, (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing), (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)) is an enzyme with systematic name (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming).[1] This enzyme catalyses the following chemical reaction

(1) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide AMP + phosphate + NADH
(2) ADP + (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate AMP + phosphate + NADPH

This enzyme acts equally well on hydrated NADH and hydrated NADPH.

References[]

  1. ^ Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL (December 2011). "Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair". The Journal of Biological Chemistry. 286 (48): 41246–52. doi:10.1074/jbc.c111.310847. PMC 3308837. PMID 21994945.

External links[]