(6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase

NAD(P)H-hydrate epimerase
Identifiers
EC number5.1.99.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

NAD(P)H-hydrate epimerase (EC 5.1.99.6, NAD(P)HX epimerase) is an enzyme with systematic name (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase.[1] This enzyme catalyses the following chemical reaction

(1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.

References[]

  1. ^ Marbaix AY, Noël G, Detroux AM, Vertommen D, Van Schaftingen E, Linster CL (December 2011). "Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair". The Journal of Biological Chemistry. 286 (48): 41246–52. doi:10.1074/jbc.c111.310847. PMC 3308837. PMID 21994945.

External links[]