(2,3-dihydroxybenzoyl)adenylate synthase

(2,3-dihydroxybenzoyl)adenylate synthase
Identifiers
EC no.2.7.7.58
CAS no.122332-73-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a (2,3-dihydroxybenzoyl)adenylate synthase (EC 2.7.7.58) is an enzyme that catalyzes the chemical reaction ATP + 2,3-dihydroxybenzoate diphosphate + (2,3-dihydroxybenzoyl)adenylate.[1]

Thus, the two substrates of this enzyme are ATP and 2,3-dihydroxybenzoate, whereas its two products are diphosphate and (2,3-dihydroxybenzoyl)adenylate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:2,3-dihydroxybenzoate adenylyltransferase. This enzyme is also called 2,3-dihydroxybenzoate-AMP ligase. This enzyme participates in biosynthesis of siderophore group nonribosomal.

References[]

  1. ^ Rusnak, Frank; Faraci, W. Stephen; Walsh, Christopher T. (1989-08-22). "Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product". Biochemistry. 28 (17): 6827–6835. doi:10.1021/bi00443a008. ISSN 0006-2960.