(-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase

Premnaspirodiene oxygenase
Identifiers
EC number1.14.13.121
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(-)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 solavetivone + 2 NADP+ + 3 H2O (overall reaction)
(1a) (-)-vetispiradiene + NADPH + H+ + O2 solavetivol + NADP+ + H2O
(1b) solavetivol + NADPH + H+ + O2 solavetivone + NADP+ + 2 H2O

Premnaspirodiene oxygenase heme-thiolate protein (P-450).

References[]

  1. ^ Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (October 2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". The Journal of Biological Chemistry. 282 (43): 31744–54. doi:10.1074/jbc.M703378200. PMC 2695360. PMID 17715131.

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