(-)-menthol monooxygenase

(−)-menthol monooxygenase
EC no.
CAS no.117590-75-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a (−)-menthol monooxygenase (EC is an enzyme that catalyzes the chemical reaction

(−)-menthol + NADPH + H+ + O2 p-menthane-3,8-diol + NADP+ + H2O

The 4 substrates of this enzyme are (−)-menthol, NADPH, H+, and O2, whereas its 3 products are p-menthane-3,8-diol, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is (−)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called l-menthol monooxygenase.


Use of (−)-menthol monooxygenase has been explored by several companies including Procter & Gamble for cleaning products.[1] [2] [3]


  1. ^ "Cleaning compositions comprising a specific oxygenase"|Alfons, Ivan Maurice et al.|https://patents.google.com/patent/EP1002040B2/en
  2. ^ "Methods for conducting assays for enzyme activity on protein microarrays"|Zhou, Fang X.; Schweitzer, Barry| https://patents.google.com/patent/US7635572B2/en?oq=US7635572B2
  3. ^ "Cleaning compositions contain a specific oxygenase"|Barnabas, Mary et al.|https://patents.google.com/patent/DE69727704T3/en